Cefoperazone and Sulbactam injection is offered under the brand name Megamax and in the dosage form of 1.5 gm. This injection is a potent antibiotic combination that is used to treat severe bacterial infections. Cefoperazone (a third-generation cephalosporin) provides broad-spectrum antibacterial activity, while Sulbactam acts as a beta-lactamase inhibitor, enhancing effectiveness against resistant bacteria.
This injection is commonly used for respiratory, urinary, abdominal, and skin infections and sepsis. It is manufactured and supplied by Max Life Sciences all over the nation. Their expert team of R&D provides effective and innovative formulations to their patients and tries to meet their unmet needs. They provide ultimate support and guidance to their PCD pharma franchise owners in different locations in India.
Advantages of Cefoperazone and Sulbactam Injection
The medical benefits of Cefoperazone and Sulbactam injection are as follows:
- Effective against Pseudomonas, E. coli, Klebsiella, S. aureus, and other resistant pathogens.
- Sulbactam prevents bacterial enzyme degradation of cefoperazone.
- Treats nosocomial pneumonia, peritonitis, meningitis, and septicemia.
- Higher success rates in polymicrobial infections.
- Flexible dosing for critical or moderate infections.
- Trusted in post-surgical prophylaxis and immunocompromised patients.
How to Use Cefoperazone and Sulbactam Injection
The usage directions of Cefoperazone and Sulbactam injection are given below:
- Administered intravenously (IV) or intramuscularly (IM) as prescribed by a doctor.
- Dosage depends on infection type, severity, and the patient’s kidney/liver function.
- Typically given every 8 to 12 hours for optimal effectiveness.
- Do not mix with other antibiotics unless directed by a healthcare provider.
- Complete the full course even if symptoms improve to prevent antibiotic resistance.
How to Store Cefoperazone and Sulbactam Injection
The storage instructions for Cefoperazone and Sulbactam injection are:
- Store in a cool, dry place away from direct sunlight.
- Keep the injection vials at a temperature not exceeding 25°C.
- Do not freeze the injection solution.
- Protect from moisture and keep the container tightly closed.
- Store in the original packaging until ready for use.
- Keep out of reach of children and pets.
- Check for discoloration or particles before use; discard if present.
- Follow hospital or pharmacy storage guidelines if applicable.
- Do not use if the seal is broken or damaged.
- Discard any unused portion as per medical waste disposal protocols.
Precautions for Cefoperazone and Sulbactam Injection
The precautions you should know before Cefoperazone and Sulbactam injection are mentioned below:
- Inform your doctor about any allergies to penicillin or cephalosporin antibiotics.
- Monitor kidney and liver function during prolonged use.
- Avoid in patients with a history of bleeding disorders or vitamin K deficiency.
- Use with caution in pregnant or breastfeeding women under medical supervision.
- May cause dizziness; avoid driving or operating machinery.
- Discontinue if severe diarrhea (possible C. difficile infection) occurs.
- Do not use beyond the prescribed duration to prevent superinfections.
Side Effects of Cefoperazone and Sulbactam Injection
The side effects of using Cefoperazone and Sulbactam injection are noted here:
- Diarrhea
- Nausea
- Rash
- Injection site pain
- Headache
- Elevated liver enzymes
- Bleeding tendency (rare)
Frequently Asked Questions (FAQs)
Can Cefoperazone and Sulbactam injection cause allergic reactions?
Yes, inform your doctor if you have a penicillin/cephalosporin allergy.
Is Cefoperazone and Sulbactam injection safe for kidney patients?
Dosage may need adjustment; consult a doctor for proper guidance.
How long does treatment usually last?
Duration depends on infection severity, typically 7–14 days.
Can pregnant women take this injection?
Only under strict medical supervision after risk-benefit analysis.
Does Cefoperazone and Sulbactam injection interact with other drugs?
Yes, inform your doctor about all medications you are taking.
Can Sulbactam and Cefoperazone injection cause diarrhea?
Yes, report severe or persistent diarrhea to your doctor.
Why is Sulbactam combined with Cefoperazone?
Sulbactam prevents bacterial resistance, enhancing cefoperazone’s effectiveness.
