Meropenem and Sulbactam injection are supplied under the brand name Ezinem SB 1.5 gm. Meropenem and Sulbactam injection is a potent combination antibiotic used to treat severe bacterial infections, including those caused by multidrug-resistant organisms. Meropenem, a carbapenem antibiotic, works by inhibiting bacterial cell wall synthesis, while Sulbactam, a beta-lactamase inhibitor, enhances its effectiveness by preventing antibiotic degradation.
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Medical Benefits of Meropenem and Sulbactam Injection
The medical advantages gained from Meropenem and Sulbactam injection are given below:
- Effective against a wide range of severe bacterial infections.
- Combats multidrug-resistant organisms due to synergistic action.
- Treats pneumonia, including hospital-acquired and ventilator-associated cases.
- Used for intra-abdominal infections such as peritonitis.
- Effective in managing septicemia (bloodstream infections).
- Treats complicated urinary tract infections (UTIs).
- Addresses skin and soft tissue infections in high-risk patients.
- Provides broad-spectrum coverage for post-surgical infections.
- Sulbactam enhances efficacy by inhibiting beta-lactamase enzymes.
- Rapid intravenous delivery ensures quick therapeutic action in critical cases.
Dosage Instructions for Meropenem and Sulbactam Injection
The dosage rules for Meropenem and Sulbactam Injection are as follows:
- Administered intravenously (IV) only, under medical supervision.
- Typical adult dose: 1 g meropenem + 0.5 g sulbactam every 8 hours.
- Severe infections may require 2 g meropenem + 1 g sulbactam every 8 hours.
- Infusion duration: 15–30 minutes for meropenem (or as prescribed).
- Dosage adjusted for renal impairment (e.g., reduced frequency if CrCl <50 mL/min).
- Pediatric dose: 20–40 mg/kg meropenem + 10–20 mg/kg sulbactam per dose (max 2g/1g).
- Do not mix with other medications in the same IV line unless compatible.
- Treatment duration: Usually 5–14 days, based on infection severity and response.
- Reconstitute with sterile water or 0.9% NaCl as per manufacturer guidelines.
- Monitor renal function and blood counts during prolonged therapy.
Storage Instructions for Meropenem and Sulbactam Injection
The tips for storing Meropenem and Sulbactam Injection are discussed here:
- Store unopened vials at controlled room temperature (20°C–25°C).
- Protect from light and moisture by keeping in the original packaging.
- Do not freeze the injection or the reconstituted solution.
- The reconstituted solution is stable for up to 3 hours at room temperature or 24 hours if refrigerated (2°C–8°C).
- Discard unused reconstituted solution after the stability period expires.
- Keep vials away from direct sunlight and heat sources.
- Ensure the storage area is out of reach of children and pets.
- Do not use if the solution appears discolored or contains particles.
- Check the expiration date before use and never administer expired medication.
- Follow hospital or clinic protocols for storage if used in a healthcare facility.
Precautions of Meropenem and Sulbactam Injection
The precautions of Meropenem and Sulbactam Injection are mentioned below:
- Consult your doctor before using this medicine.
- Monitor for allergic reactions; discontinue immediately if rash, itching, or anaphylaxis occurs.
- Assess renal function before and during therapy; adjust dose in renal impairment.
- May cause seizures in high doses or patients with CNS disorders; use cautiously in epilepsy.
- Prolonged use can lead to superinfections like candidiasis or C. difficile-associated diarrhea.
- Avoid in pregnancy unless needed; potential fetal risks exist (Category B).
- Monitor liver enzymes; may cause transient elevations in AST/ALT.
- Use cautiously in elderly patients due to age-related renal decline.
- Inform the healthcare provider of all medications to avoid drug interactions (e.g., valproic acid).
- Do not administer via intramuscular or oral routes; IV infusion only.
Side Effects of Meropenem and Sulbactam Injection
The negative effects caused by Meropenem and Sulbactam Injection are:
- Allergic reactions
- Seizure risk
- Diarrhea common
- Nausea/vomiting
- Headache possible
- Rash may occur
- Liver enzyme changes
- Kidney function alterations
- Low platelet count
- Injection site reactions
- Fever occasionally
- Candida overgrowth
- Dizziness reported
- Abdominal pain
